We anticipate that this will decrease incorrect or uncertain diagnoses with resulting psychological and financial cost to the patient. The overarching goal is to improve diagnostic accuracy with the use of ambulatory EEG in patients with their FSUS. One-year follow-up of each patient will be used to assess recurrence of seizures after a FSUS and the utility of the ambulatory EEG to forecast these recurrences.ĭiscussion: To the best of our knowledge, this will be the first study to prospectively examine the use of ambulatory EEG for a FSUS in adults and its use for prediction of recurrence of seizures. The three EEG (first routine EEG as gold standard) will be compared and evaluated their diagnostic accuracy (sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratios) with respect of epileptiform activity and other abnormalities. These patients will be assessed by a neurologist/epileptologist with the first routine EEG (referral EEG) and undergo a second routine EEG and ambulatory EEG.
Methods: The DX-Seizure study is a prospective cohort of 113 adult patients (≥18-year-old) presenting with FSUS to the Single Seizure Clinic for evaluation.
Functional Imagingįunctional imaging tests such as positron emission tomography (PET), single-photon emission computed tomography (SPECT), and functional MRI (fMRI) scans map your blood flow, energy use, and membrane receptors in specific brain regions. Ambulatory EEGīy wearing electrodes at home for 48-72 hours, your team can monitor and capture your brain activity during typical spells/seizures, allowing your care team to diagnose and effectively treat you.Ī primary diagnostic service of the Epilepsy Center, structural neuroimaging, detects lesions, and biochemical dysfunction that cause epilepsy. These tools include beginning with the least invasive and most common: Routine Electroencephalography (EEG)īy recording your brain's electrical activity, an EEG can determine if abnormal brainwaves-aids in diagnosing seizures and other neurologic disorders-are present. The Center uses both time-tested and groundbreaking diagnostic tools to identify the causes, type, and severity of your epilepsy.
The Epilepsy Center offers comprehensive epilepsy diagnosis, treatment, and rehabilitation services.